Dandelion extract: Inhibition of triple-negative breast cancer through metabolic interventions
Current research shows that dandelion extract is not only valued in traditional medicine, but also has enormous potential in fighting cancer. The study by Wang et al. (2022) examines the effect of the extract on triple-negative breast cancer (TNBC), a particularly aggressive and difficult-to-treat type of cancer.
study overview
The study combined modern analytical methods such as network pharmacology and multi-omics techniques to understand the mechanisms of action of dandelion extract against TNBC. In vitro and in vivo studies were conducted to analyze the effect on cell proliferation and metabolic processes.
- Title: Dandelion extract inhibits triple-negative breast cancer cell proliferation by interfering with glycerophospholipids and unsaturated fatty acids metabolism
- Authors: Shan Wang, Hui-Feng Hao, Yan-Na Jiao, et al.
- Journal: Frontiers in Pharmacology (2022)
- Link to the study: Dandelion Extract in TNBC
results of the study
Research highlights several mechanisms of action:
- Inhibition of cell proliferation: Dandelion extract significantly reduced the growth of TNBC cells.
- Regulation of lipid metabolism: The extract influenced the metabolism of glycerophospholipids and unsaturated fatty acids, which are relevant for tumor development.
- Modulation of key signaling pathways: The extract downregulated CHKA expression and inhibited the PI3K/AKT/SREBP/FADS2 axis, important metabolic pathways in cancer growth.
relevance for everyday life
The results underline the potential of dandelion extract in complementary cancer therapy. Due to its natural properties and targeted effect on lipid metabolism, the extract could be a promising approach to support difficult-to-treat cancers.
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